Introduction: Introduction: AOD-9604 is a synthetic peptide fragment of human growth hormone (hGH 177191) engineered to replicate hGHs fat-metabolism effects without altering IGF-1 or glucose levels. In preclinical research, it promoted lipolysis (fat breakdown) and reduced lipogenesis (fat storage) through receptor-independent mechanisms. AOD-9604 Fast Facts Class: Synthetic hGH fragment analog (Tyr-hGH 177191) Intended purpose: Stimulate fat metabolism while avoiding hGHs growth or glucose effects Mechanism: Increases fat oxidation, enhances lipolysis, suppresses lipogenesis Distinct from hGH: Does not activate the growth hormone receptor or raise IGF-1 Development stage: Completed Phase II trials
In one program, a separate NNMT inhibitor reduced 1-methylnicotinamide levels and improved insulin sensitivity and glucose tolerance in DIO mice, with these effects absent in NNMT-knockout animals
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Its action is specific to adipocytes (fat cells) via beta-3 adrenergic receptors and does not affect anabolic pathways, protein synthesis signaling, or IGF-1 levels
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